Boston Patients who are treated with proton treatment (a specialized type of external beam radiation treatment using protons rather than X-rays to treat cancer) decreases the risk of patients developing a secondary cancer by two hundred percent, in comparison to being treated with standard photon radiation therapy, as per a first-of-its-kind study presented September 22, 2008, at the American Society for Therapeutic Radiology and Oncology's 50th Annual Meeting in Boston.

This study contradicts recent theories that have suggested that proton radiation might actually increase instead of decrease the occurence rate of secondary cancers because of what is called scatter radiation. When proton radiation is delivered, neutrons are produced by nuclear interactions and are therefore scattered as a result.

"This study could have a substantial impact on the care of patients," Nancy Tarbell, M.D., senior author of the study and a radiation oncologist at the Massachusetts General Hospital in Boston, said. "Since cancer patients are surviving for longer periods of time, side effects of treatment are becoming increasingly important for doctors to consider when developing therapy plans. Since this is a retrospective study, however, we will need additional studies to further prove this hypothesis".

Photon radiation is the standard external beam radiation treatment therapy, while proton radiation is a more targeted form of external beam radiation which delivers less radiation to bordering normal structures. During external beam radiation treatment, a beam of radiation is directed through the skin to the cancer and the immediate surrounding area in order to destroy the main tumor and any nearby cancer cells.

The retrospective cohort study matched 503 patients who underwent Harvard Cyclotron proton radiation therapy with 1,591 patients treated with photon radiation treatment from the Surveillance, Epidemiology, and End Results (SEER) cancer registry from 1974 to 2001. As per the study, 6.4 percent of patients who underwent proton treatment developed a secondary cancer while 12.8 percent of patients who had photon therapy developed another type of cancer.


Posted by: Andria    Source

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