http://www.thecancerblog.org/ New Article Alert From From Thecancerblog Thu, 07 Jul 2011 15:03:30 GMT en-us http://www.thecancerblog.org/images/blogs/thecancerblog.jpg http://www.thecancerblog.org/ 100 125 http://www.thecancerblog.org/blogs/permalinks/7-2011/amrubicin-improved-response-rate.html http://www.thecancerblog.org/blogs/permalinks/7-2011/amrubicin-improved-response-rate.html Thu, 07 Jul 2011 15:03:30 GMT ung cancer patients given amrubicin (Calsed) as a second-line treatment had a significantly improved response rate and longer progression-free survival than patients treated with topotecan (Hycamtin), as per research presented at the 14th World Conference on Lung Cancer in Amsterdam, hosted by the International Association for the Study of Lung Cancer (IASLC)........ ]]> http://www.thecancerblog.org/blogs/permalinks/4-2011/thalidomide-as-adjuvant-therapy-for-hcc.html http://www.thecancerblog.org/blogs/permalinks/4-2011/thalidomide-as-adjuvant-therapy-for-hcc.html Thu, 07 Jul 2011 15:03:30 GMT Thalidomide has shown potential to be used as the first adjuvant treatment for hepatocellular carcinoma (HCC), as per data presented at the International Liver CongressTM 2011.1. A newly released study found thalidomide gave HCC patients who'd undergone grossly curative resection surgical removal of the malignant part of the liver double the two-year disease free survival rate (65%) in comparison to placebo (33%)........ ]]> http://www.thecancerblog.org/blogs/permalinks/4-2011/possible-treatment-for-prostate-cancer.html http://www.thecancerblog.org/blogs/permalinks/4-2011/possible-treatment-for-prostate-cancer.html Thu, 07 Jul 2011 15:03:30 GMT Researchers have identified digoxin as a possible treatment for prostate cancer, using a combination of laboratory science and epidemiology that is unprecedented in its cooperative nature. "Epidemiologists and basic researchers often do not understand each other, as we often are only clear on our own strengths and the other's weaknesses," said Elizabeth Platz, Sc.D., M.P.H, professor of epidemiology and the Martin D. Abeloff, M.D., scholar in cancer prevention at Johns Hopkins University........ ]]> http://www.thecancerblog.org/blogs/permalinks/4-2011/alternate-method-of-prostate-cancer-diagnosis.html http://www.thecancerblog.org/blogs/permalinks/4-2011/alternate-method-of-prostate-cancer-diagnosis.html Thu, 07 Jul 2011 15:03:30 GMT Scientists have observed that it may not be necessary to look for tumors directly in prostate cancer patients � analyzing non-tumor tissue appears to be an effective option, as per study results published in Cancer Research, a journal of the American Association for Cancer Research. "A biopsy needle does not need to hit a tumor to detect the presence of tumor," said lead researcher Dan Mercola, M.D., Ph.D., professor of pathology and laboratory medicine at the University of California at Irvine. "It is reminiscent of the game Battleship; we can detect more cancer cases using 12 shots with a biopsy needle than would otherwise be the case because we have made the ships bigger"........ ]]> http://www.thecancerblog.org/blogs/permalinks/3-2011/outcome-in-chronic-myeloid-leukemia.html http://www.thecancerblog.org/blogs/permalinks/3-2011/outcome-in-chronic-myeloid-leukemia.html Thu, 07 Jul 2011 15:03:30 GMT While the median age at diagnosis for chronic myeloid leukemia (CML) is over 60 years old and incidence increases dramatically with age,limited data are available about the long-term outcome for older patients treated with imatinib, the standard first-line treatment used to treat CML. Results from a study published recently in Blood, the Journal of the American Society of Hematology, reveal that age does not affect response to imatinib and study researchers conclude that overall survival for CML is similar in older and younger patients treated with the drug........ ]]> http://www.thecancerblog.org/blogs/permalinks/3-2011/rotein-that-protects-cancer-cells.html http://www.thecancerblog.org/blogs/permalinks/3-2011/rotein-that-protects-cancer-cells.html Thu, 07 Jul 2011 15:03:30 GMT Research led by Daitoku Sakamuro, PhD, Assistant Professor of Pathology at LSU Health Sciences Center New Orleans and the LSUHSC Stanley S. Scott Cancer Center, has identified a protein that enables the activation of a DNA-repair enzyme that protects cancer cells from catastrophic damage caused by chemo and radiation treatment. This protein, called c-MYC oncoprotein, can initiate and promote almost all human cancers and discovering the role it plays in cancer therapy resistance may lead to advances that save lives. The work is reported in the March 29, 2011 issue of Science Signaling, a publication of the American Association for the Advancement of Science. Eventhough researchers have known that cancer cells can acquire resistance to DNA-damaging therapeutic agents, the genetic mechanisms through which this occurs have remained unclear until now........ ]]> http://www.thecancerblog.org/blogs/permalinks/3-2011/combining-two-peptide-inhibitors.html http://www.thecancerblog.org/blogs/permalinks/3-2011/combining-two-peptide-inhibitors.html Thu, 07 Jul 2011 15:03:30 GMT newly released study suggests that combining two experimental anticancer peptide agents might simultaneously block formation of new tumor blood vessels while also inhibiting the growth of tumor cells. This early test of the two agents in a breast cancer model suggests that the double hit can stifle tumor progression, avoid drug resistance and cause few side effects, say scientists at the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) who developed the agents and reviewed their effectiveness in laboratory and animal tests........ ]]> http://www.thecancerblog.org/blogs/permalinks/3-2011/compound-may-lead-to-drugs-to-fight-cancer.html http://www.thecancerblog.org/blogs/permalinks/3-2011/compound-may-lead-to-drugs-to-fight-cancer.html Thu, 07 Jul 2011 15:03:30 GMT Scientists at UT Southwestern Medical Center have identified a chemical compound that may eventually lead to a drug that fights cancers that are dependent on a particular anti-viral enzyme for growth. The scientists are testing the compound's effectiveness at fighting tumors in mice. If it is successful, they will then work to develop a drug based on the compound to combat pancreatic and non-small cell lung cancer, two cancer types in which this particular enzyme, TBK-1, often is mandatory for cancer cell survival........ ]]> http://www.thecancerblog.org/blogs/permalinks/3-2011/role-of-damaged-dna-in-tumor-development.html http://www.thecancerblog.org/blogs/permalinks/3-2011/role-of-damaged-dna-in-tumor-development.html Thu, 07 Jul 2011 15:03:30 GMT DNA provides the instruction manual for all life forms. Occasionally, instructions are not carried out properly, and bad messages are sent leading to the creation of mutant proteins and possible tumor development. Paul Doetsch, PhD, professor of radiation oncology and biochemistry and associate director for basic research at Emory's Winship Cancer Institute and Damien Bregeon, PhD, at Institut de Genetique et Microbiologie in Paris, have outlined the role this process - known as transcriptional mutagenesis - might play in tumor development in a Nature Reviews Cancer article published online February 24th and in the March 2011 print edition........ ]]> http://www.thecancerblog.org/blogs/permalinks/3-2011/prostate-cancer-treatment-is-different.html http://www.thecancerblog.org/blogs/permalinks/3-2011/prostate-cancer-treatment-is-different.html Thu, 07 Jul 2011 15:03:30 GMT Prostate cancer is always a very scary diagnosis and one that many men do not know exactly what to do with. There are some ways that you can look at prostate cancer treatment and determine your course of treatment. Looking at the treatments that have proven to be the most successful can help you determine where you are going to go next. ....... ]]> http://www.thecancerblog.org/blogs/permalinks/1-2011/profiling-to-detect-abnormalities-including-cancer.html http://www.thecancerblog.org/blogs/permalinks/1-2011/profiling-to-detect-abnormalities-including-cancer.html Thu, 07 Jul 2011 15:03:30 GMT An Ohio State University mathematician and colleagues are finding ways to tell the difference between healthy cells and abnormal cells, such as cancer cells, based on the way the cells look and move. They are creating mathematical equations that describe the shape and motion of single cells for laboratory analysis........ ]]> http://www.thecancerblog.org/blogs/permalinks/1-2011/why-psa-levels-reflect-prostate-cancer-progression.html http://www.thecancerblog.org/blogs/permalinks/1-2011/why-psa-levels-reflect-prostate-cancer-progression.html Thu, 07 Jul 2011 15:03:30 GMT Scientists at the Duke Cancer Institute who have been studying prostate cancer cells for decades now think they know why PSA (prostate-specific antigen) levels reflect cancer progression. "This is the first demonstration of a mechanism that explains why PSA is a bad thing for a tumor to produce," said senior author Sal Pizzo, M.D., Ph.D., chair of the Duke Department of Pathology. "I am willing to bet there is also a connection in malignant cell growth with this particular biological signaling mechanism happening in other types of cells"........ ]]> http://www.thecancerblog.org/blogs/permalinks/1-2011/detecting-esophageal-cancer-with-light.html http://www.thecancerblog.org/blogs/permalinks/1-2011/detecting-esophageal-cancer-with-light.html Thu, 07 Jul 2011 15:03:30 GMT A tiny light source and sensors at the end of an endoscope may provide a more accurate way to identify pre-malignant cells in the lining of the esophagus. Developed by biomedical engineers at Duke University and successfully tested on patients during a clinical trial at the University of North Carolina at Chapel Hill, the device holds the promise of being a less invasive method for testing patients suspected of having Barrett's esophagus, a change in the lining of the esophagus due to acid reflux. Acid reflux occurs when stomach acid splashes, or refluxes, up into the esophagus........ ]]> http://www.thecancerblog.org/blogs/permalinks/1-2011/parallels-between-cancers-infection-suppression.html http://www.thecancerblog.org/blogs/permalinks/1-2011/parallels-between-cancers-infection-suppression.html Thu, 07 Jul 2011 15:03:30 GMT Tiny parasitoid wasps can play an important role in controlling the populations of other insect species by laying their eggs inside the larvae of these species. A newly hatched wasp gradually eats the host alive and takes over its body. The host insect is far from defenseless, however. In Drosophila (fruit flies), larvae activate humoral immunity in the fat body and mount a robust cellular response that encapsulates and chokes off the wasp egg........ ]]> http://www.thecancerblog.org/blogs/permalinks/1-2011/breast-reconstruction-choosing-implants.html http://www.thecancerblog.org/blogs/permalinks/1-2011/breast-reconstruction-choosing-implants.html Thu, 07 Jul 2011 15:03:30 GMT diagnosis of breast cancer and the fight that follows often represent a highly emotional, challenging time for a number of women and their families. In particular, medical procedures such as mastectomy (removal of a breast) can shake a woman's most basic sense of identity and leave equally devastating emotional scars. As part of the rebuilding process, a number of women elect to undergo breast reconstruction surgery. Performed by a plastic surgeon, this procedure returns the breast to a similar shape, size, and look (e.g., the nipple and areola can also be reconstructed). Some women choose to have the surgery immediately after the mastectomy whereas others wait until radiation treatment has been completed. Eventhough there are a number of reasons why women decide to have breast reconstruction, it is important to thoroughly weigh the risks and benefits with your physician-including when to have surgery, what type of procedure to select, and which implant if applicable-as far in advance as possible........ ]]>