Anti-cancer Drug Made From Corn LilliesA drug that shuts down a critical cell-signaling pathway in the most common and aggressive type of adult brain cancer successfully kills cancer stem cells thought to fuel tumor growth and help cancers evade drug and radiation treatment, a Johns Hopkins study shows.
In a series of laboratory and animal experiments, Johns Hopkins researchers blocked the signaling system, known as Hedgehog, with an experimental compound called cyclopamine to........Go to the The-cancer-blog (Added on 8/30/2007 9:28:55 PM)
Novel M.S. Drug Against LeukemiasA new study suggests that an experimental drug being tested for the therapy of multiple sclerosis and to prevent organ rejection might also help people with certain deadly forms of chronic and acute leukemia.
The laboratory and animal study focused on the drug, called fingolimod. Scientists said it might help patients with advanced chronic myelogenous leukemia (CML) or acute lymphocytic leukemia (ALL), and whose cancer cells show a........Go to the The-cancer-blog (Added on 8/28/2007 8:55:49 PM)
Tumors use enzyme to recruitOne way tumors fly under the radar of the immune system is by using IDO, an enzyme used by fetuses to help avoid rejection, to recruit powerful regulatory T cells that turn down the immune response, scientists say.
It was known tumors assemble a protective barrier of regulatory T cells, or Tregs, but how they are such able recruiters was an unknown, says Dr. David Munn, pediatric hematologist/oncologist at the Medical College of Georgia........Go to the The-cancer-blog (Added on 8/16/2007 8:58:16 PM)
Birth records hold pancreatic cancer cluePregnancies in Jerusalem in the 1960s and 1970s may hold vital clues about how pancreas cancer and diabetes are linked. As per research reported in the online open access journal BMC Medicine, women with a history of gestational diabetes had a higher risk of developing pancreas cancer during the later part of life.
The research team drawn from the US and Israel and led by M. C. Perrin traced over 37,000 mothers who gave birth between 1964........Go to the Cancer-articles (Added on 8/15/2007 9:28:55 PM)
COX-2 inhibitors delay pancreatic cancer precursorsNimesulide, a cyclooxygenase-2 (COX-2) inhibitor, delays the progression of premalignant pancreatic lesions in mice, as per scientists at David Geffen School of Medicine at UCLA. While inflammation has been shown to be a factor in a number of forms of cancer, the scientists say this is the first study to demonstrate the effect of an anti-inflammatory COX-2 inhibitor on the development of pancreas cancer.
The study, reported in the August 1........Go to the The-cancer-blog (Added on 8/1/2007 9:15:37 PM)
Treatment target found in Hodgkin lymphomaDana-Farber Cancer Institute researchers have identified a protein that prevents the body's immune system from recognizing and attacking Hodgkin lymphoma cells. Based on this finding, the scientists are now investigating targeted therapies to disable this molecular "bodyguard" and boost a patient's ability to fight the blood cancer.
If the strategy proves successful, patients might escape some of the long-term complications -- like heart........Go to the The-cancer-blog (Added on 7/30/2007 10:03:47 PM)
Beat Cancer Through ArtKhaleej Times has published this noteworthy print advertisement to in its fund raising effort to fight breast cancer. The double-edged advertisement has married two aspects, art and increasing problem of breast cancer. In fact, the advertisement campaign was launched with a view to attract peoples attention towards an exhibition of paintings whose collection will be given to an organization involved in fighting this menacing problem. The........Go to the The-cancer-blog (Added on 7/24/2007 10:10:39 PM)
Any Tumor Cell To Best Possible Anti-cancer TreatmentsCancer patients dont have time to waste. A number of go through several different therapys, however, to find one that is more effective against their particular type of tumor.
Thus, an algorithm that could help rapidly sort molecular information about a patients particular tumor and could help match this information to the right drug therapy would be a breakthrough of enormous value.
Dan Theodorescu, M.D., Ph.D., a University of Virginia........Go to the The-cancer-blog (Added on 7/23/2007 5:15:14 PM)
Molecular detectors may refine cancer treatmentUniversity of Florida scientists have successfully used molecular probes to detect subtle differences in leukemia cells from patient samples, an achievement that could lead to more effective ways to diagnose and treat cancer.
The strategy, described in a recent issue of Clinical Chemistry, involves engineering short, single strands of DNA or RNA called aptamers to seek out and bind with specific proteins in body fluids.
UF researchers........Go to the The-cancer-blog (Added on 7/19/2007 10:07:00 PM)
hope for childhood cancer sufferersResearchers investigating drug therapies for children with Acute Lymphoblastic Leukaemia (ALL) have presented new data demonstrating for the very first time that a small molecule called ABT-737 can increase the effectiveness of standard therapies.
Dr Richard Lock, Head of the Leukaemia Biology Program at the Childrens Cancer Institute Australia for Medical Research, Sydney, along with collaborators from the Childrens Hospital Los Angeles and........Go to the The-cancer-blog (Added on 7/16/2007 10:04:14 PM)
Nanoparticles that cancer cells can't resistTURNING cancer cells into mini magnets by using nanoparticles could make biopsies so sensitive and efficient that there will be no need to repeat these invasive tests.
Biopsy results can be ambiguous: sometimes they can be negative simply because there are too few cancerous cells in the sample to be detected not because all trace of disease has gone. Now scientists from the University of New Mexico and the company Senior Scientific, both in........Go to the The-cancer-blog (Added on 7/12/2007 5:46:43 AM)
Kaposi sarcoma arises independently from multiple cellsKaposi sarcoma is unique among cancers because most tumors grow from a small number of different cells, whereas nearly all other cancers arise from a single cell, as per a research studypublished online July 10 in the Journal of the National Cancer Institute
Kaposi sarcoma, which is often linked to AIDS, primarily affects the skin. But as the disease progresses, it can move to the lymph nodes and internal organs as well.
Renan Duprez,........Go to the The-cancer-blog (Added on 7/11/2007 5:19:28 AM)
More Lethal Subtype Of AMLA new study shows that the activity of a particular gene can identify people who have a more lethal form of acute myeloid leukemia, singling out those patients who should receive more intense treatment.
The gene, called ERG (for ETS-related gene), has also been associated with chronic leukemia and to breast and prostate cancer.
The findings apply to acute myeloid leukemia (AML) patients with leukemia cells that have normal-looking........Go to the The-cancer-blog (Added on 7/10/2007 5:06:19 AM)
Electric Pulses To Destroy Cancer CellsA team of biomedical engineers at Virginia Tech and the University of California at Berkeley has developed a new minimally invasive method of treating cancer, and they anticipate clinical trials on individuals with prostate cancer will begin soon.
The process, called irreversible electroporation (IRE), was invented by two engineers, Rafael V. Davalos, a faculty member of the Virginia TechWake Forest University School of Biomedical........Go to the The-cancer-blog (Added on 7/5/2007 9:40:03 PM)
DNA Discoveries in Science and ArtHere is a great video about Rosalind Franklin who made the first clear X-ray images of the structure of DNA. She died of ovarian cancer at the age of 37! So artists Wyllie O Hagan try to “use their art to support awareness raising missions for ovarian cancer”.........Go to the The-cancer-blog (Added on 7/2/2007 10:26:05 PM)
Key To Understanding Cancer DevelopmentA research team including University of Central Florida Microbiology Professor Keith Ireton is using the bacterial pathogen Listeria Monocytogenes to understand the mechanisms of cell growth and cancer development.
In research published this month in the Journal of Biological Chemistry, the team observed that a Listeria protein called InlB induces internalization and degradation of a human receptor known as Met. Met has been implicated in........Go to the The-cancer-blog (Added on 6/28/2007 11:39:01 PM)
Computerized Physician Order Entry SystemThe occurence rate of medicine errors can be reduced by implementing a computerized doctor order entry (CPOE) system, as per a review of several studies conducted by scientists at the University of Minnesota.
The review, recently reported in the online journal Health Services Research, analyzed 12 studies conducted between 1990 and 2005 that compared the number of handwritten and computerized medicine errors made by hospital physicians.........Go to the What-media-blog (Added on 6/27/2007 7:00:15 PM)
Characterizing Aggressiveness Of Cancer CellsLevels of a small non-coding RNA molecule called let-7 appear to define different stages of cancer better than some of the "classical" markers for tumor progression, scientists from the University of Chicago report in the June 25, 2007, early online edition of the Proceedings of the National Academy of Sciences.
By suppressing genes that are active in the developing embryo, silenced just before birth, and re-activated years later in a number........Go to the The-cancer-blog (Added on 6/25/2007 7:55:14 PM)
Treatment Slows The Growth Of Cancers Of The Colon And LiverLeire García Navarro, a researcher at the School of Pharmacy of the University of Navarra, has developed a new therapy which slows the growth of colon and liver cancers.
This discovery is the principal result of her doctoral dissertation, entitled "Lipo-Polymeric Vectors for the Transfer of DNA in Cancer Cells of the Colon", which was subsidized by the Basque Government. In order to carry out the study, this scientist of the Department of........Go to the The-cancer-blog (Added on 6/22/2007 4:46:43 AM)
Target tumor microenvironment to stop cancer growthCold Spring Harbor Laboratory (CSHL) scientists led by Daniel Nolan and Assistant Professor Vivek Mittal have observed that bone marrow (BM) derived endothelial progenitor cells (EPCs) play a critical role in the early stages of tumor progression and that eliminating EPCs stops cancer growth. Using sophisticated high-resolution microscopy and flow cytometry, they zeroed in on the earliest stages of cancer progression and identified the role of........Go to the The-cancer-blog (Added on 6/15/2007 12:24:19 PM)
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molecular pathway to predict chemotherapy effectivenessA common molecular pathway could help physicians predict which patients with lung cancer will benefit from chemotherapy drugs, as per new research from a multidisciplinary team at the University of Cincinnati (UC).
Known as the retinoblastoma (RB) tumor suppressor, this fundamental molecule regulates cell proliferation in the body. Research has shown that the RB pathway is either entirely inactive or altered in most human cancers.........Go to the The-cancer-blog (Added on 9/3/2007 12:55:40 PM)
Cells united against cancerSheets of highly organized epithelial cells line all the cavities and free surfaces of the body, forming barriers that control the movement of liquids and cells in the body organs. The organized structure of normal breast epithelial cells may also serve as a barrier against cancer, as per a research studyby University of Helsinki scientists. The work appears this week in the online edition of the Proceedings of the National Academy of Sciences........Go to the The-cancer-blog (Added on 8/27/2007 9:43:38 PM)
New cancer weapon: nuclear nanocapsulesRice University chemists have found a way to package some of nature's most powerful radioactive particles inside DNA-sized tubes of pure carbon -- a method they hope to use to target tiny tumors and even lone leukemia cells.
"There are no FDA-approved cancer therapies that employ alpha-particle radiation," said lead researcher Lon Wilson, professor of chemistry. "Approved therapies that use beta particles are not well-suited for treating........Go to the The-cancer-blog (Added on 8/23/2007 10:16:44 PM)
Light-activated Molecules To Kill Cancer CellsA key challenge facing doctors as they treat patients suffering from cancer or other diseases resulting from genetic mutations is that the drugs at their disposal often dont discriminate between healthy cells and dangerous ones -- think of the brute-force approach of chemotherapy, for instance. To address this challenge, Florida State University researchers are investigating techniques for using certain molecules that, when exposed to light,........Go to the The-cancer-blog (Added on 8/8/2007 8:44:41 PM)
Marijuana and virus that causes Kaposi's sarcomaThe major active component of marijuana could enhance the ability of the virus that causes Kaposis sarcoma to infect cells and multiply, according to a team of researchers at Harvard Medical School. According to the researchers, low doses of -9 tetrahydrocannabinol (THC), equivalent to that in the bloodstream of an average marijuana smoker, could be enough to facilitate infection of skin cells and could even coax these cells into malignancy.
........Go to the The-cancer-blog (Added on 8/1/2007 9:32:28 PM)
Aggressive Therapy Best For Certain AML PatientsA new study suggests that acute leukemia patients whose cancer cells show a genetic change that commonly predicts a swift return of the disease following remission may remain disease-free longer when given aggressive treatment.
The findings apply to people with acute myeloid leukemia (AML) whose cancer cells have normal-looking chromosomes and a gene mutation called MLL-PTD.
Typically, these AML patients responded poorly following therapy........Go to the The-cancer-blog (Added on 8/1/2007 9:07:31 PM)
Low Cholesterol Levels And CancerMillions of Americans take statins to lower their cholesterol, but how low should you go" Many scientific studies support the benefits of lowering low-density lipoprotein (LDL) cholesterol, and achieving low LDL cholesterol levels is one of the most important steps in preventing heart disease. New research, however, provides evidence for an association between low LDL levels and cancer risk.
The authors of the study, published in the July........Go to the The-cancer-blog (Added on 7/23/2007 6:40:45 PM)
Sperm banking before treatment preserves fertilityA recent study at Hamilton Health Sciences proves that sperm freezing and banking is an effective way to preserve fertility in adolescents and young adult (AYA) males with cancer.
Scientists at the Centre for Reproductive Care, McMaster Childrens Hospital and the Juravinski Cancer Centre, all members of the Hamilton Health Sciences family of health care facilities, joined forces to investigate the benefits of proactively preserving sperm........Go to the The-cancer-blog (Added on 7/23/2007 6:17:38 PM)
Impact of False-positive Cancer TestsAs per a new study in Value in Health, women coping with the strain of being mistakenly diagnosed with breast cancer have not been adequately studied in the past. The focus of the study is a new survey that accurately assesses the negative effects of false diagnosis and provides useful information to health care practitioners and researchers.
"We know that having a false alarm at a breast cancer screening causes significant negative........Go to the The-cancer-blog (Added on 7/19/2007 9:55:05 PM)
Elevated Leukaemia Rates Near Nuclear FacilitiesLeukaemia rates in children and young people are elevated near nuclear facilities, but no clear explanation exists to explain the rise, according to a research review published in the recent issue of European Journal of Cancer Care.
Researchers at the Medical University of South Carolina carried out a sophisticated meta-analysis of 17 research papers covering 136 nuclear sites in the UK, Canada, France, the USA, Germany, Japan and Spain.
........Go to the Cancer-articles (Added on 7/18/2007 9:39:06 PM)
Tumor painting against cancerA tumor paint developed by scientists at Seattle Childrens Hospital Research Institute and Fred Hutchinson Cancer Research Center will help surgeons see where a tumor begins and ends more precisely by illuminating the malignant cells. The study, reported in the July 15, 2007 issue of Cancer Research, shows that the tumor paint can help surgeons distinguish between cancer cells and normal brain tissue in the operating room. The paint is a........Go to the The-cancer-blog (Added on 7/15/2007 9:21:52 PM)
How Cancer Drug WorksThe annoying bulges of an over-wound telephone cord that shorten its reach and limit a callers motion help to explain why drugs called camptothecins are so effective in killing cancer cells, as per researchers at St. Jude Children's Research Hospital and Delft University of Technology.
Using a type of nanotechnology called magnetic tweezers as well as yeast cells, researchers showed that a camptothecin drug called topotecan kills cancer........Go to the The-cancer-blog (Added on 7/10/2007 5:30:11 AM)
genes associated with colon cancerA 10-year study involving thousands of Israeli Jews and Arabs, led by scientists from American and Israeli institutions, has yielded important new information in the search for the genes that make a person more likely to develop colon cancer.
In a paper would be reported in the recent issue of Cancer Biology and Therapy, the international research team reports finding a significant link between genetic variation in a single region of human........Go to the The-cancer-blog (Added on 7/8/2007 10:14:06 PM)
Skin Rash Actually Signifies Better OutcomesThe appearance of a rash in cancer patients treated with erlotinib (Tarceva) is strongly linked to longer survival, as per scientists from the drug's developer, OSI Pharmaceuticals, Inc. This is not the first time that rash has been linked to a survival advantage with EGFR inhibitors - a class of drugs which includes erlotinib, cetuximab, panitumumab and others designed to block overproduction of the epidermal growth factor receptor - but it is........Go to the Cancer-articles (Added on 7/3/2007 9:39:51 PM)
How Cancer Evades The Immune SystemOne of the fundamental traits of a tumor how it avoids the immune system might become its greatest vulnerability, as per scientists from the University of Southern California. Their findings, demonstrated in human breast and colorectal cancers, indicate that a technique for determining a tumors immune signature, could be useful for diagnosing and treating specific cancers.
In the July 1 issue of Clinical Cancer Research, a publication of........Go to the The-cancer-blog (Added on 7/2/2007 10:03:54 PM)
Pairing Nanoparticles with ProteinsIn groundbreaking research, researchers have demonstrated the ability to strategically attach gold nanoparticles - particles on the order of billionths of a meter - to proteins so as to form sheets of protein-gold arrays. The nanoparticles and methods to create nanoparticle-protein complexes can be used to help decipher protein structures, to identify functional parts of proteins, and to "glue" together new protein complexes. Applications........Go to the What-media-blog (Added on 6/27/2007 7:04:00 PM)
Support for chromosomal theory of cancerBerkeley Thirty-six years into the war on cancer, researchers have not only failed to come up with a cure, but most of the newer drugs suffer from the same problems as those available in the pre-war days: serious toxicity, limited effectiveness and eventual resistance.
This is no surprise to University of California, Berkeley, genetics researcher Peter Duesberg, professor of molecular and cell biology. As per his novel yet controversial........Go to the The-cancer-blog (Added on 6/27/2007 6:39:06 PM)
Bisphosphonates And Osteonecrosis Of Jaw BoneTreatment with intravenous bisphosphonates drugs used to reduce harm done to bones by cancer or cancer treatment increases the risk of jaw or facial bone disease or infection, a large-scale comparative study by scientists at the University of Texas Medical Branch at Galveston (UTMB) has found.
Drawing on the National Cancer Institutes Surveillance, Epidemiology and End Results (SEER) database associated with Medicare insurance claims,........Go to the The-cancer-blog (Added on 6/26/2007 10:34:49 PM)
Cigarette smoking impairs ligament healingThe list of reasons you shouldn't smoke has gotten longer. Scientists at Washington University School of Medicine in St. Louis are reporting that smoking interferes with ligament healing.
Studying mice with knee ligament injuries, the team discovered cigarette smoking impairs the recruitment of cells to the injury site and delays healing following ligament-repair surgery. They reported their findings in the Journal of Orthopaedic Research.
........Go to the Cancer-articles (Added on 6/22/2007 4:43:55 AM)
FISH on a chip offers quicker, less costly cancer diagnosisFor the first time an important diagnostic test for cancer has been miniaturized and automated onto a microfluidic chip by a team of University of Alberta scientists in Edmonton, Canada.
This new technology opens up the possibility of better, faster cancer therapy and greater accessibility to the test, thanks to quicker and more cost-efficient diagnosis.
Chris Backhouse, professor of electrical engineering and cancer scientist Dr. Linda........Go to the The-cancer-blog (Added on 6/20/2007 10:14:13 AM)
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